This executive order bans federal funding and support for gender-affirming care for minors, defining such care as potentially harmful 'chemical and surgical mutilation.' It directs federal agencies to rescind policies relying on the World Professional Association for Transgender Health (WPATH) guidance, conduct literature reviews on best practices for children with gender dysphoria, and take steps to prevent these procedures through various means including Medicare/Medicaid, TRICARE, and the Federal Employee Health Benefits program.

The order also instructs the Department of Justice to investigate potential fraud and abuse related to these procedures and to support legislation providing legal recourse for affected children and families.

This Presidential order directs the creation and implementation of a next-generation missile defense shield for the United States.

It mandates the development of a comprehensive plan within 60 days, including space-based interceptors and non-kinetic capabilities, to counter advanced missile threats.

The order also emphasizes international collaboration on missile defense and ensures that this initiative is consistent with existing laws and budget considerations.

The Presidential Action, dated January 23, 2025, seeks to advance U.S. leadership in artificial intelligence by revoking previous directives that were barriers to innovation.

It establishes policies prioritizing AI development free from bias, mandates an action plan within 180 days, and outlines immediate review and amendments to prior orders and regulations to align with the new policy goals.

In January 2025, the President established the President's Council of Advisors on Science and Technology (PCAST) to promote American leadership in scientific and technological innovation.

Addressing the urgency to maintain global dominance in transformative technologies, the order emphasizes creating a diverse advisory body that advises on policy and provides strategic oversight in science, technology, education, and innovation.